Progress in the structure and function of human carboxylesterase 1 / 生物工程学报
Chinese Journal of Biotechnology
;
(12): 1414-1422, 2012.
Artigo
em Chinês
| WPRIM
| ID: wpr-342385
ABSTRACT
Human carboxylesterase 1 (HCE1), belonging to a multigene serine hydrolase family, is a major liver carboxylesterase responsible for the hydrolysis and metabolism of various xenobiotics. It also plays an important role in the transportation and metabolism of endogenous cholesterol ester and free fatty acid, and is closely associated with the pathogenesis of hepatocellular carcinoma. This review describes current developments in the molecular structure, the roles in drug, toxins and lipid metabolism, and the early diagnosis for hepatocellular carcinoma of human carboxylesterase 1.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fisiologia
/
Hidrolases de Éster Carboxílico
/
Xenobióticos
/
Ésteres do Colesterol
/
Carcinoma Hepatocelular
/
Diagnóstico
/
Ácidos Graxos não Esterificados
/
Genética
/
Neoplasias Hepáticas
/
Metabolismo
Tipo de estudo:
Estudo diagnóstico
/
Estudo de rastreamento
Limite:
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Biotechnology
Ano de publicação:
2012
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS