Pharmacological interventions for phantom limb pain / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 542-549, 2013.
Artigo
em Inglês
| WPRIM
| ID: wpr-342547
ABSTRACT
<p><b>OBJECTIVE</b>To review the mechanisms and current clinical application of pharmacological interventions for phantom limb pain.</p><p><b>DATA SOURCES</b>Both Chinese and English language literatures were searched using MEDLINE (1982 - 2011), Pubmed (1982 - 2011) and the Index of Chinese Language Literature (1982 - 2011).</p><p><b>STUDY SELECTION</b>Data from published articles about pharmacological management of phantom limb pain in recent domestic and foreign literature were selected. Data extraction Data were mainly extracted from 96 articles which are listed in the reference section of this review.</p><p><b>RESULTS</b>By reviewing the mechanisms and current clinical application of pharmacological interventions for phantom limb pain, including anticonvulsants, antidepressants, local anaesthetics, N-methyl-D-aspartate receptor antagonists, non-steroidal anti-inflammatory drugs, tramadol, opioids, calcitonin, capsaicin, beta-adrenergic blockers, clonidine, muscle relaxants, and emerging drugs, we examined the efficacy and safety of these medications, outlined the limitations and future directions.</p><p><b>CONCLUSIONS</b>Although there is lack of evidence-based consensus guidelines for the pharmacological management of phantom limb pain, we recommend tricyclic antidepressants, gabapentin, tramadol, opioids, local anaesthetics and N-methyl-D-aspartate receptor antagonists as the rational options for the treatment of phantom limb pain.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Membro Fantasma
/
Tramadol
/
Usos Terapêuticos
/
Tratamento Farmacológico
/
Analgésicos
/
Analgésicos Opioides
/
Anticonvulsivantes
/
Antidepressivos
Tipo de estudo:
Guia de Prática Clínica
Limite:
Humanos
Idioma:
Inglês
Revista:
Chinese Medical Journal
Ano de publicação:
2013
Tipo de documento:
Artigo
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