RNA interference in functional genomics and medical research / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 848-851, 2004.
Artigo
em Chinês
| WPRIM
| ID: wpr-342597
ABSTRACT
RNA interference (RNAi) is a post-transcriptional gene silencing process by targeting mRNA for degradation in a sequence-specific manner. This powerful platform has enormous potential in functional genomics and medical research. As a tool to knock out expression of specific genes in a variety of organisms, RNAi was used to investigate gene function in a high throughput fashion. Highly conserved in evolution RNAi appears to have evolved as a cellular defense mechanism in plants and animals to suppress viral infection, transposon jumping and endogenous aberrant genes. Exploiting the natural mechanism, the researchers can shut down disease-causing genes and develop novel therapeutics against infection, tumor and other disease.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Regulação da Expressão Gênica
/
Inativação Gênica
/
Genômica
/
Complexo de Inativação Induzido por RNA
/
RNA Interferente Pequeno
/
Interferência de RNA
Idioma:
Chinês
Revista:
Journal of Biomedical Engineering
Ano de publicação:
2004
Tipo de documento:
Artigo
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