The Effect of Mosapride on Quality of Life in Functional Dyspepsia / 대한소화기학회지
The Korean Journal of Gastroenterology
;
: 160-167, 2004.
Artigo
em Coreano
| WPRIM
| ID: wpr-34265
ABSTRACT
BACKGROUND/AIMS:
It is unknown whether the prokinetics improve the quality of life in patients with functional dyspepsia. Thus, we evaluate the effect of the mosapride, selective 5-HT4 agonist, on the symptom and life quality of patients with functional dyspepsia using the Nepean dyspepsia index-Korean version (NDI-K), a reliable and validated disease-specific quality of life questionnaire.METHODS:
A single, open trial was performed in 129 patients with functional dyspepsia. Patients were received mosapride 5 mg t.i.d before each meal for 4 weeks. The symptoms and quality of life were measured with the NDI-K at baseline and 4 weeks. The responsiveness of the NDI-K was evaluated by correlation with symptom scores.RESULTS:
All the 15 symptom scores and the dyspepsia score decreased after treatment (p<0.05). The total symptom score decreased from 60.9 +/- 25.8 to 24.7 +/- 20.4 (p=0.001). Correlations were observed between the total symptom score and the NDI-K score (r=0.47, p=0.001), and between the total symptom score and each score in 5 subscales (r=0.25-0.44, p=0.001). The NDI-K score was significantly increased in the effective group whose dyspepsia score decreased more than 50% of the score at baseline, compared with that of ineffective group. Any significant adverse effect and prolongation of QT interval were not occurred in all patients.CONCLUSIONS:
A prokinetic drug, mosapride improves the symptoms and the quality of life in patients with functional dyspepsia.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Qualidade de Vida
/
Benzamidas
/
Fármacos Gastrointestinais
/
Resumo em Inglês
/
Morfolinas
/
Inquéritos e Questionários
/
Antagonistas de Dopamina
/
Dispepsia
Limite:
Adulto
/
Idoso
/
Feminino
/
Humanos
/
Masculino
Idioma:
Coreano
Revista:
The Korean Journal of Gastroenterology
Ano de publicação:
2004
Tipo de documento:
Artigo
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