Structural feature and biological function of PPP2R5C gene / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 1127-1129, 2009.
Artigo
em Chinês
| WPRIM
| ID: wpr-343334
ABSTRACT
PPP2R5C is one of the members of regulatory subunits of protein phosphatase 2A (PP2A), which plays a critical role in cell proliferation, differentiation and transformation, based on its induction of dephosphorylation of P53 at various residues. Recently, it was characterized that the alteration of expression pattern of PPP2R5C is associated with cell malignant transformation, thus PPP2R5C was thought as a marker for progressive disease in B-CLL. In this article the gene structure and biological function of PPP2R5C as well as relation of PPP2R5C with genesis and development of cancer were discussed.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Linhagem Celular Transformada
/
Estrutura Molecular
/
Transformação Celular Neoplásica
/
Subunidades Proteicas
/
Proliferação de Células
/
Proteína Fosfatase 2
/
Genética
Limite:
Humanos
Idioma:
Chinês
Revista:
Journal of Experimental Hematology
Ano de publicação:
2009
Tipo de documento:
Artigo
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