Study on vasorelaxations of oxyphenamone and its mechanism / 药学学报
Acta Pharmaceutica Sinica
;
(12): 10-13, 2002.
Artigo
em Chinês
| WPRIM
| ID: wpr-343411
ABSTRACT
<p><b>AIM</b>To study the vasorelaxation action of oxyphenamone (Oxy) and its mechanism.</p><p><b>METHODS</b>The contractile response of isolated rabbit renal, femoral and mesentery artery preparations was determined.</p><p><b>RESULTS</b>Oxy was shown to inhibit the contractile force of renal, femoral and mesentery arteries induced by phenylephrine in a concentration dependent manner. The vasorelaxation produced by Oxy was not attenuated by removal of the endothelium. Oxy (10(-6)-10(-4) mol.L-1) relaxed the contractions induced by KCl 30 mmol.L-1 as well as KCl 80 mmol.L-1, but the contraction curve of KCl 80 mmol.L-1 was shifted significantly to the right. Oxy in lower concentration (10(-6) and 5 x 10(-6) mol.L-1) increased the contractions induced by Ang II, and in middle concentration (10(-5) mol.L-1) it did not affect the contractions induced by Ang II. Whereas in higher concentration (5 x 10(-5) mol.L-1) it obviously inhibited the contractions induced by Ang II.</p><p><b>CONCLUSION</b>Oxy showed significant vasorelaxation to various vascular preparations, and its vasorelaxation action is endothelium independent. The mechanism of its vasorelaxations seems to be related with Ca2+ activated K+ channel (Kca channel) and Ca2+ channel in vascular smooth muscle cells but its true mechanism needs further study.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Compostos Orgânicos
/
Farmacologia
/
Fenilefrina
/
Fisiologia
/
Artéria Renal
/
Vasodilatação
/
Vasodilatadores
/
Técnicas In Vitro
/
Cardiotônicos
/
Canais de Potássio Cálcio-Ativados
Limite:
Animais
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2002
Tipo de documento:
Artigo
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