Effect of neostigmine on atracurium-induced neuromuscular blockage in patients pretreated with magnesium sulphate / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
; (6): 111-114, 2005.
Article
em Zh
| WPRIM
| ID: wpr-343756
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WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To determine the effect of neostigmine on antagonizing atracurium-induced neuromuscular blockage with sulfate magnesium pretreatment.</p><p><b>METHODS</b>Forty patients who undertook elective gynecologic laparoscopic examinations and treatments under general anesthesia were randomized into four groups (group A, B, C, and D, group A paired with group C, and group B paired with group D). Before induction of general anesthesia, patients in group A and group C received MgSO4 30 mg/kg in saline intravenously within 5 min, while patients in group B and group D received the same volume of saline. Anesthesia was induced with fentanyl and propofol; subsequently tracheal intubation was performed with 0.5 mg/kg atracurium after stabilization of the electromyography recording, and neostigmine (0.02 mg/kg) and atropine (0.01 mg/kg) were infused in group C and group D when neuromuscular recovery (T1/T(C)) reached 10%. T1/T(C) changes after neostigmine infusion as well as haemodynamic changes and other responses during induction and neostigmine and atropine infusion were recorded.</p><p><b>RESULTS</b>The neuromuscular recovery speed had no significant difference between group A and group B after the neuromuscular recovery reached 10%, but it was lower in group C than in group D (P < 0.05). Significant difference existed between group AC and group BD (P < 0.05). No haemodynamic changes and other responses were found during induction and neostigmine and atropine infusion.</p><p><b>CONCLUSION</b>Neostigmine-induced neuromuscular recovery can be attenuated in patients pretreated with magnesium sulfate.</p>
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Assunto principal:
Farmacologia
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Atracúrio
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Inibidores da Colinesterase
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Fármacos Neuromusculares não Despolarizantes
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Laparoscopia
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Bloqueio Neuromuscular
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Anestesia Geral
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Sulfato de Magnésio
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Neostigmina
Tipo de estudo:
Clinical_trials
Limite:
Adolescent
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Adult
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Female
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Humans
Idioma:
Zh
Revista:
Acta Academiae Medicinae Sinicae
Ano de publicação:
2005
Tipo de documento:
Article