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Analysis of the relationship between Glut-4 gene polymorphism and blood-fat traits in induced hyperglycemia mice / 药学学报
Acta Pharmaceutica Sinica ; (12): 931-934, 2009.
Artigo em Chinês | WPRIM | ID: wpr-344016
ABSTRACT
This study is to investigate the effect of diet and gene on blood-fat trait of the individual mouse. One hundred and twenty mice were fed with high fat emulsion for 4 weeks. Then the genotypes of Glut-4 were analyzed by PCR-SSCP to investigate the effect on blood-fat traits and some organ performance of mice. After fed with high fat emulsion for 4 weeks, 98 mice suffered from hyperlipidemia, while 22 mice did not. And a T/A mutation was found in 188 targeted fragments we amplified at 8,521 site, and association analysis showed that the mice carried BB genotype had higher TC, TG and LW/BW level than those of the mice with AA genotype (P < 0.05). Different Glut-4 genotypes show different sensitivities to high fat emulsion on mice.
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Sangue / Polimorfismo de Nucleotídeo Único / Transportador de Glucose Tipo 4 / Genética / Hiperglicemia / Lipídeos / Camundongos Obesos Limite: Animais Idioma: Chinês Revista: Acta Pharmaceutica Sinica Ano de publicação: 2009 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Sangue / Polimorfismo de Nucleotídeo Único / Transportador de Glucose Tipo 4 / Genética / Hiperglicemia / Lipídeos / Camundongos Obesos Limite: Animais Idioma: Chinês Revista: Acta Pharmaceutica Sinica Ano de publicação: 2009 Tipo de documento: Artigo