Analysis of the relationship between Glut-4 gene polymorphism and blood-fat traits in induced hyperglycemia mice / 药学学报
Acta Pharmaceutica Sinica
;
(12): 931-934, 2009.
Artigo
em Chinês
| WPRIM
| ID: wpr-344016
ABSTRACT
This study is to investigate the effect of diet and gene on blood-fat trait of the individual mouse. One hundred and twenty mice were fed with high fat emulsion for 4 weeks. Then the genotypes of Glut-4 were analyzed by PCR-SSCP to investigate the effect on blood-fat traits and some organ performance of mice. After fed with high fat emulsion for 4 weeks, 98 mice suffered from hyperlipidemia, while 22 mice did not. And a T/A mutation was found in 188 targeted fragments we amplified at 8,521 site, and association analysis showed that the mice carried BB genotype had higher TC, TG and LW/BW level than those of the mice with AA genotype (P < 0.05). Different Glut-4 genotypes show different sensitivities to high fat emulsion on mice.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Sangue
/
Polimorfismo de Nucleotídeo Único
/
Transportador de Glucose Tipo 4
/
Genética
/
Hiperglicemia
/
Lipídeos
/
Camundongos Obesos
Limite:
Animais
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2009
Tipo de documento:
Artigo
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