Synthesis and biological evaluation of 3-quinolinecarbonitrile-7-amide derivatives / 药学学报
Acta Pharmaceutica Sinica
;
(12): 879-884, 2009.
Artigo
em Chinês
| WPRIM
| ID: wpr-344025
ABSTRACT
A series of N-(3-cyano-6-methyl-4-anilinoquinoline-7-yl) amide derivatives 13a-13n have been synthesized, their structures were confirmed with 1H NMR, EI-MS, IR and elemental analysis. Antitumor activities of all the synthesized compounds in vitro were tested with MTT. Compound 13j showed better than or equal antitumor activity on Bosutinib and EKB-569.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Quinolinas
/
Química
/
Linhagem Celular Tumoral
/
Compostos de Anilina
/
Antineoplásicos
Limite:
Humanos
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2009
Tipo de documento:
Artigo
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