Advances in the study of organelles targeting nanocarriers / 药学学报
Acta Pharmaceutica Sinica
; (12): 838-844, 2009.
Article
em Zh
| WPRIM
| ID: wpr-344032
Biblioteca responsável:
WPRO
ABSTRACT
Modern drug delivery system demands high therapeutic efficacy and low toxicity which depends on efficient intracellular transportation of therapeutics to specific organisms, cells, even targeted organelles such as cytosol, nucleus, mitochondria, lysosome and endoplasmic reticulum. Intracellular barriers which prevent drug molecules accessing to their targets mainly include cell membrane, lysosomal degradation and the endomembrane system. Nanocarriers can preserve the bioactivities of protein, enzyme and DNA, and also they are easy to be modified and functionalized. In this paper, we summarized the intracellular fate of nanocarriers, especially how to bypass intracellular barriers and then target cytosol, nucleus, mitochondria, lysosome and endoplasmic reticulum by pharmaceutical modifications.
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Portadores de Fármacos
/
Organelas
/
Sistemas de Liberação de Medicamentos
/
Nanopartículas
Limite:
Animals
/
Humans
Idioma:
Zh
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2009
Tipo de documento:
Article