Synthesis and anti-histamine release activity of phenyl tetrazole compounds / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1112-1117, 2009.
Artigo
em Chinês
| WPRIM
| ID: wpr-344048
ABSTRACT
Ongoing effort to find novel antiasthmatic drugs led to the design and synthesis of a series of compounds bearing phenyl tetrazole group based on the SAR study. The important intermediate 3-(1H-tetrazol-5-yl) benzenamine was synthesized from m-nitroaniline via cyclization and hydrogenation. Followed by amidation, eight new target compounds were obtained. The structures of these compounds were confirmed with 1H NMR, ESI-MS and elemental analysis. Their non-specific and specific anti-histamine effects in the mast cell were determined. Compound NP03 could inhibit non-specific histamine release induced by compound 48/80 in mast cell of SD rats.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Relação Estrutura-Atividade
/
Tetrazóis
/
Estrutura Molecular
/
Química
/
Ratos Sprague-Dawley
/
P-Metoxi-N-metilfenetilamina
/
Antiasmáticos
/
Liberação de Histamina
/
Mastócitos
Limite:
Animais
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2009
Tipo de documento:
Artigo
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