Synthesis and anti-tumor activities of N-(aminopyridine) benzamide derivaties / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1376-1382, 2009.
Artigo
em Chinês
| WPRIM
| ID: wpr-344068
ABSTRACT
To explore novel histone deacetylase (HDAC) inhibitors with anti-tumor activity, on the basis of preliminary studies, sixteen N-(2-amino-4-pyridine) benzamide derivaties (class A) and sixteen N-(2-amino-3-pyridine) benzamide derivaties (class B) were designed and prepared, and their structures were confirmed by 1H NMR and HR-MS individually. The results showed that 30 target compounds except V-20 and V-21 had HDACs inhibitory activity and V -13, V -14, V -16 were equal to CI-994 at 200 micromol x L(-1) in vitro. Compounds V-30, V-31 and V-32 exhibited potent inhibitory activities on Hut78, Jurkat E6-1, A549, K562 and MDA-MB-435s.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Benzamidas
/
Ensaios de Seleção de Medicamentos Antitumorais
/
Química
/
Linhagem Celular Tumoral
/
Inibidores de Histona Desacetilases
/
Histona Desacetilases
/
Metabolismo
/
Antineoplásicos
Limite:
Humanos
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2009
Tipo de documento:
Artigo
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