Progress on targeting TRAIL's receptor as antitumor strategy / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1336-1342, 2009.
Artigo
em Chinês
| WPRIM
| ID: wpr-344075
ABSTRACT
There exist two major apoptotic signaling pathways the intrinsic mitochondria-mediated pathway, and the extrinsic death receptor-induced pathway. TNF-related apoptosis-inducing ligand (TRAIL), which is the ligand for death receptor 4 (DR4) and death receptor 5 (DR5) and induces apoptosis by ligation with DR4 or DR5. We review the characteristic of TRAIL and its receptors, the mechanism of apoptosis induced by TRAIL, the distribution of death receptors in cancer, and applications and prospects of TRAIL signaling pathway in the treatment of cancer.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Farmacologia
/
Terapêutica
/
Terapia Genética
/
Transdução de Sinais
/
Classificação
/
Sistemas de Liberação de Medicamentos
/
Apoptose
/
Usos Terapêuticos
/
Ligante Indutor de Apoptose Relacionado a TNF
Limite:
Animais
/
Humanos
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2009
Tipo de documento:
Artigo
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