Advances in study of metabolic activation of carboxyl-acid containing drugs by UGTs / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1193-1199, 2009.
Artigo
em Chinês
| WPRIM
| ID: wpr-344094
ABSTRACT
The metabolic transformation of the drugs containing carboxylic acid groups can lead to the formation of acyl glucuronide metabolites through catalysis by glucuronosyltransferase, and produce pro-acyl glucuronide intermediate metabolites with electronic activity. Then, protein or DNA adducts appeared after a series of non-enzyme or enzyme reactions. These adducts would change the protein activity and potentially lead to idiosyncratic and genotoxicity. In this paper, we discussed the chemical activity, drug-induced mechanisms, distribution and toxicity resulting from this metabolic activation for these drugs, and stated the status and prospects of research in this field.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Transporte Biológico Ativo
/
Dano ao DNA
/
Ácidos Carboxílicos
/
Preparações Farmacêuticas
/
Biotransformação
/
Glucuronosiltransferase
/
Glucuronídeos
/
Hepatócitos
/
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos
/
Toxicidade
Limite:
Humanos
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2009
Tipo de documento:
Artigo
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