Association of HSPA1A gene single nucleotide polymorphisms with the development of cervical cancer among ethnic Han Chinese from Yunnan / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 909-914, 2017.
Article
em Zh
| WPRIM
| ID: wpr-344147
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WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To assess the association of four single nucleotide polymorphisms (SNPs) (rs12190359C>T, rs562047C>G, rs1008438G>T, and rs1043618G>C) of HSPA1A gene with the development of cervical cancer among ethnic Han Chinese from Yunnan.</p><p><b>METHODS</b>One hundred and thirty patients with CIN III, 444 patients with cervical cancer, and 548 healthy individuals were recruited, and the genotypes of the above SNPs were determined with a Taqman assay. Haplotypes were constructed, and their association with the development of cervical cancer was analyzed.</p><p><b>RESULTS</b>The frequencies of G and T alleles of rs1008438G>T were significant different between the CIN III and control groups, as well as between the cancer and control groups (P=0.022 and P=0.030, respectively). There was a significant difference in genotypic frequency of rs1008438G>T between the CIN III and control groups (P=0.047). The allelic and genotypic frequencies of rs12190359C>T, rs562047C>G, and rs1043618G>C did not significantly differ between the CIN III, cervical cancer and control groups (P> 0.05). The frequencies of haplotypes formed by rs562047C>G, rs1008438G>T and rs1043618G>C also did not significantly differ between the CIN III, cancer and control groups (P> 0.05).</p><p><b>CONCLUSION</b>The G allele of rs1008438G>T may be a protective factor for cervical cancer among ethnic Han Chinese from Yunnan.</p>
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Índice:
WPRIM
Assunto principal:
Haplótipos
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Neoplasias do Colo do Útero
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China
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Proteínas de Choque Térmico HSP70
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Predisposição Genética para Doença
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Polimorfismo de Nucleotídeo Único
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Etnologia
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Genética
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Genótipo
Limite:
Female
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Humans
País/Região como assunto:
Asia
Idioma:
Zh
Revista:
Chinese Journal of Medical Genetics
Ano de publicação:
2017
Tipo de documento:
Article