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Association of aggressive behaviors of schizophrenia with short tandem repeats loci / 中华医学遗传学杂志
Chinese Journal of Medical Genetics ; (6): 901-904, 2017.
Artigo em Chinês | WPRIM | ID: wpr-344149
ABSTRACT
<p><b>OBJECTIVE</b>To assess the association of short tandem repeats (STRs) loci with aggressive behaviors of schizophrenia.</p><p><b>METHODS</b>Blood samples from 123 schizophrenic patients with aggressive behaviors and 489 schizophrenic patients without aggressive behaviors were collected. DNA from all samples was amplified with a PowerPlex 21 system and separated by electrophoresis to determine the genotypes and allelic frequencies of 20 STR loci including D3S1368, D1S1656, D6S1043, D13S317, Penta E, D16S639, D18S51, D2S1338, CSF1PO, Penta D, TH01, vWA, D21S11, D7S820, D5S818, TPOX, D8S1179, D12S391, D19S433, and FGA.</p><p><b>RESULTS</b>All of the 20 STR loci have reached Hardy-Weinberg equilibrium in both groups. A significant difference was found in allelic and genotypic frequencies of loci Penta D between the two groups (alleles P=0.042; genotypes P=0.014) but not for the remaining 19 loci (P> 0.05). Univariate analysis also showed a significant difference for allele 10 and genotypes 10-12 of Penta D between the two groups (P=0.0027, P=0.0001), with the OR being 1.81 (95%CI 1.22-2.67) and 4.33 (95%CI 1.95-9.59), respectively.</p><p><b>CONCLUSION</b>Penta D may be associated with aggressive behaviors of schizophrenia. Allele 10 and genotypes 10-12 of Penta D may confer a risk for the disease.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Esquizofrenia / Repetições de Microssatélites / Agressão / Frequência do Gene / Genética / Genótipo Limite: Adolescente / Adulto / Idoso / Humanos Idioma: Chinês Revista: Chinese Journal of Medical Genetics Ano de publicação: 2017 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Esquizofrenia / Repetições de Microssatélites / Agressão / Frequência do Gene / Genética / Genótipo Limite: Adolescente / Adulto / Idoso / Humanos Idioma: Chinês Revista: Chinese Journal of Medical Genetics Ano de publicação: 2017 Tipo de documento: Artigo