Progress in genetic research on essential tremor / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 767-771, 2017.
Artigo
em Chinês
| WPRIM
| ID: wpr-344178
ABSTRACT
Essential tremor (ET) is one of the most common movement disorders. Its clinical manifestations not only include typical kinetic and/or postural tremors, but also other non-motor symptoms such as cognitive dysfunction, sleep disturbance, and dysosmia. The exact etiology and pathogenesis of ET is still unknown. Approximately 60% of ET patients have a family history, and genetic factor plays an important role in the onset of the disease. Researchers have so far identified 3 genetic loci (ETM 1-3) through family studies, and proposed additional causative genes such as FUS, HTRA2, TENM4, NOS3 and susceptibility genes such as LINGO, SLC1A2, and GABA. This review focuses on the progress made in genetic research on ET.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Predisposição Genética para Doença
/
Tremor Essencial
/
Proteína FUS de Ligação a RNA
/
Pesquisa em Genética
/
Serina Peptidase 2 de Requerimento de Alta Temperatura A
/
Genética
/
Proteínas de Membrana
/
Proteínas do Tecido Nervoso
Tipo de estudo:
Estudo prognóstico
Limite:
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Medical Genetics
Ano de publicação:
2017
Tipo de documento:
Artigo
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