Medication-related osteonecrosis of the jaw: a preliminary retrospective study of 130 patients with multiple myeloma / 대한악안면성형재건외과학회지
Maxillofacial Plastic and Reconstructive Surgery
;
: 1-2017.
Artigo
em Inglês
| WPRIM
| ID: wpr-34431
ABSTRACT
BACKGROUND:
Multiple myeloma (MM) is characterized by a neoplastic proliferation of plasma cells primarily in the bone marrow. Bisphosphonates (BP) are used as supportive therapy in the management of MM. This study aimed to analyze the incidence, risk factors, and clinical outcomes of medication-related necrosis of the jaw (MRONJ) in MM patients.METHODS:
One hundred thirty MM patients who had previous dental evaluations were retrospectively reviewed. Based on several findings, we applied the staging and treatment strategies on MRONJ. We analyzed gender, age, type of BP, incidence, and local etiological factors and assessed the relationship between these factors and the clinical findings at the first oral examination.RESULTS:
MRONJ was found in nine male patients (6.9%). The mean patient age was 62.2 years. The median BP administration time was 19 months. Seven patients were treated with a combination of IV zoledronate and pamidronate, and two patients received single-agent therapy. The lesions were predominantly located in the mandible (n = 8), and the most common predisposing dental factor was a history of prior extraction (n = 6). Half of the MRONJ were related to diseases found on the initial dental screen. Patients with MRONJ were treated with infection control and antibiotic therapy. When comparing between the MRONJ stage and each factor (sign, location, etiologic factor, BP type, treatment, and outcome), there were no significant differences between stages, except for between the stage and sign (with or without purulence).CONCLUSIONS:
For prevention of MRONJ, we recommend routine dental examinations and treatment prior to starting BP therapy.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Osteonecrose
/
Plasmócitos
/
Medula Óssea
/
Incidência
/
Estudos Retrospectivos
/
Fatores de Risco
/
Controle de Infecções
/
Diagnóstico Bucal
/
Difosfonatos
/
Arcada Osseodentária
Tipo de estudo:
Estudo diagnóstico
/
Estudo de etiologia
/
Estudo de incidência
/
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
Limite:
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Maxillofacial Plastic and Reconstructive Surgery
Ano de publicação:
2017
Tipo de documento:
Artigo
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