Determination of dimethyl sulphate residual in granisetron hydrochloride by headspace gas chromatography / 浙江大学学报·医学版

ABSTRACT

<p><b>OBJECTIVE</b>To develop a headspace gas chromatography method for determining dimethyl sulphate residual in granisetron hydrochloride.</p><p><b>METHODS</b>An Angilent INNOWAX capillary column with nitrogen gas as carrier and FID as detector was applied in this study. Dimethyl sulphate was tested under a constant column temperature.</p><p><b>RESULT</b>Dimethyl sulphate had different retention time from other organic solvents such as alcohol,acetoacetate, isopropanol, dichlormethane and chloroform, which might exist in granisetron hydrochloride. The detection limit of dimethyl sulphate;s was 0.0016%.</p><p><b>CONCLUSION</b>The method can be used for the determination of dimethyl sulphate residual in granisetron hydrochloride.</p>