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Effect of preoperative transcatheter arterial chemo-embolization on activity of cell proliferation in Wilms; tumor / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences ; (6): 83-87, 2008.
Artigo em Chinês | WPRIM | ID: wpr-344372
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of preoperative transcatherter arterial chemo-embolization (TACE) on the cell proliferation in Wilms; tumor.</p><p><b>METHODS</b>Forty-one cases of Wilms; tumor diagnosed by histopathology were divided into two groups in TACE group, 23 patients received TACE first and were operated 2 weeks later; in control group, 18 patients were operated alone. A comparative analysis of the pathological finding was made in two groups, and the expression of PCNA and VEGF in tumor tissue was detected by immunohistochemistry.</p><p><b>RESULT</b>The degeneration of tumor tissue such as tumor cell necrotic, broken, disappearance occurred in 17 cases of TACE group and in 4 cases of control group, respectively (P <0.01). The expression of PCNA in TACE group and in control group was 1/23 (4.3 %) and 9/18(50.0 %), respectively (P <0.01). VEGF was expressed in 7/23 (30.4 %) of TACE group and 9/18 (50.0 %) of control group (P=0.283).</p><p><b>CONCLUSION</b>TACE can significantly inhibit proliferation and enhance degeneration of Wilms; tumor cells.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Patologia / Cirurgia Geral / Terapêutica / Cuidados Pré-Operatórios / Quimioembolização Terapêutica / Tumor de Wilms / Antígeno Nuclear de Célula em Proliferação / Fator A de Crescimento do Endotélio Vascular / Proliferação de Células / Neoplasias Renais Limite: Criança / Criança, pré-escolar / Feminino / Humanos / Lactente / Masculino Idioma: Chinês Revista: Journal of Zhejiang University. Medical sciences Ano de publicação: 2008 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Patologia / Cirurgia Geral / Terapêutica / Cuidados Pré-Operatórios / Quimioembolização Terapêutica / Tumor de Wilms / Antígeno Nuclear de Célula em Proliferação / Fator A de Crescimento do Endotélio Vascular / Proliferação de Células / Neoplasias Renais Limite: Criança / Criança, pré-escolar / Feminino / Humanos / Lactente / Masculino Idioma: Chinês Revista: Journal of Zhejiang University. Medical sciences Ano de publicação: 2008 Tipo de documento: Artigo