Hepatitis B virus genotypes and the heterogeneity of its polymerase gene / 中华肝脏病杂志
Chinese Journal of Hepatology
;
(12): 265-267, 2003.
Artigo
em Chinês
| WPRIM
| ID: wpr-344428
ABSTRACT
<p><b>OBJECTIVE</b>To study the heterogeneity of polymerase gene (P gene) within hepatitis B virus (HBV) genotypes based on a systematic analysis of 202 HBV P genes, providing some useful references for further studies on the relationship among HBV genotypes, P gene mutations, replication and nucleoside analogues drug-resistance.</p><p><b>METHODS</b>202 HBV complete sequences containing P genes were obtained from GenBank and were analysed using computer softwares.</p><p><b>RESULTS</b>There were some genotype-related characteristics of HBV P genes. As reverse transcriptase domain was concerned, there were more amino acid divergences in genotype C and D compared with these in genotype A. There were also amino acid substitutions in the A-F conserved regions of the reverse transcriptase domain within and between HBV genotypes.</p><p><b>CONCLUSIONS</b>There are divergences of P genes and amino acids within and between HBV genotypes, which should be considered when amino acid changes are analyzed whether they are proposed to be drug-resistance mutations or the results from quasispecies-selected. Moreover, these divergences may affect the antiviral effect of nucleoside analogues on HBV with different genotypes.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Filogenia
/
Fisiologia
/
DNA Viral
/
Dados de Sequência Molecular
/
Produtos do Gene pol
/
Vírus da Hepatite B
/
Sequência de Aminoácidos
/
Heterogeneidade Genética
/
DNA Polimerase Dirigida por DNA
/
Genética
Limite:
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Hepatology
Ano de publicação:
2003
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS