Release mechanism of huperzine-A swelling sustained-release tablets / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 1795-1798, 2009.
Article
em Zh
| WPRIM
| ID: wpr-344534
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the release mechanism of Huperzine-A swelling sustained-release tablets (HA-ST) and the factors influencing the release rate.</p><p><b>METHOD</b>The HA-ST were prepared by using Polyoxyethylene (PEO) as the matrix material, polyvinyl alcohol (PVA) as the expandable reagent and microcrystalline cellulose (MCC) as the filling reagent. The effect of the amount of PEO, PVA and MCC on the drug release from the tablets was evaluated using the release index n value of the Ritger-Peppas equation.</p><p><b>RESULT</b>The addition of PEO and PVA speeded up the rate of drug release from the tablets, while MCC did not affect the release rate. The release profiles of HA-ST conformed to the Higuchi model and the release mechanism was non-Fick release that coupled diffusion and erosion.</p><p><b>CONCLUSION</b>The release of HA-ST is influenced by the amount of PEO and PVA but not the MCC. The release process can be depicted by the Ritger-Peppas equation and release mechanism was is non-Fick release.</p>
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Polietilenoglicóis
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Sesquiterpenos
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Comprimidos
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Farmacocinética
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Celulose
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Química
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Preparações de Ação Retardada
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Difusão
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Alcaloides
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Modelos Biológicos
Tipo de estudo:
Prognostic_studies
Idioma:
Zh
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2009
Tipo de documento:
Article