Effects of mechanical stimulation on expression of integrin subunits in chondrocyte / 中国骨伤
China Journal of Orthopaedics and Traumatology
;
(12): 266-268, 2011.
Artigo
em Chinês
| WPRIM
| ID: wpr-344630
ABSTRACT
Osteoarthritis (OA) is a kind of degenerative disease characterized by hyperosteogeny at the joint margins and articular cartilage degeneration. Mechanical stress can regulate the multiple functions of cells. The integrin as one of the mechanoreceptors on the surface of cells, mainly mediated adhesion between cells and extracellular matrix, which plays an important role in the mechanical signal transmission to regulate the physiological functions of cell. Therefore, it is very important to select proper mechanical stimulation (such as naprapathy) in the early and middle stage of osteoarthritis, which regulate the expression of integrins to affect the function of chondrocytes, repair the damaged chondrocyte and delay the articular cartilage degeneration.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Fenômenos Biomecânicos
/
Integrinas
/
Regulação da Expressão Gênica
/
Condrócitos
/
Subunidades Proteicas
/
Biologia Celular
/
Fenômenos Mecânicos
/
Metabolismo
Limite:
Animais
/
Humanos
Idioma:
Chinês
Revista:
China Journal of Orthopaedics and Traumatology
Ano de publicação:
2011
Tipo de documento:
Artigo
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