Association of polymorphisms in testosterone 5-alpha-reductase II genotype and prognosis factors of prostate cancer / 中华外科杂志
Chinese Journal of Surgery
;
(12): 1493-1496, 2004.
Artigo
em Chinês
| WPRIM
| ID: wpr-345058
ABSTRACT
<p><b>OBJECTIVE</b>The correlation were studied between testosterone 5-alpha-reductase II (SRD5A2) gene polymorphisms and prognosis factors.</p><p><b>METHODS</b>V89L and A49T variants was identified with Mwo1 and Rsa1. The differences of V89L and A49T between cancer of prostate (CaP) and benign prostatic hyperplasia (BPH) were studied. In addition, we also researched the association of polymorphisms with age of onset, free prostate specific antigen (FPSA), total PSA (TPSA), FPSA/TPSA (F/T), Gleason score, and T stage in cancer group.</p><p><b>RESULTS</b>We found no differences of V89L and A49T polymorphisms between CaP and BPH. In CaP group the A49T variant was associated with lower age of onset (P = 0.03) and higher Gleason score (P = 0.015). There were no differences between VV and VL+LL polymorphisms with any of the characteristics studied. When the characteristics above were regarded as two-level discrete variable, there were no differences by A49T and V89Lvariants.</p><p><b>CONCLUSION</b>In CaP group, the AT+TT genotype was perhaps associated with poor prognosis. VL+LL genotype has no relation with prognosis.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Polimorfismo Genético
/
Prognóstico
/
Hiperplasia Prostática
/
Neoplasias da Próstata
/
3-Oxo-5-alfa-Esteroide 4-Desidrogenase
/
Sangue
/
Antígeno Prostático Específico
/
Predisposição Genética para Doença
/
Frequência do Gene
Tipo de estudo:
Estudo prognóstico
Limite:
Idoso
/
Aged80
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Surgery
Ano de publicação:
2004
Tipo de documento:
Artigo
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