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Haplotype and linkage analysis in Chinese hereditary mixed polyposis syndrome / 中华胃肠外科杂志
Chinese Journal of Gastrointestinal Surgery ; (12): 312-315, 2005.
Artigo em Chinês | WPRIM | ID: wpr-345185
ABSTRACT
<p><b>OBJECTIVE</b>To investigate if hereditary mixed polyposis syndrome (HMPS) locus of two Singapore Chinese HMPS families is identical with the Ashkenazi families.</p><p><b>METHODS</b>Genomic DNA was extracted, multiplex polymerase chain reaction (PCR) was used to amplify 4 microsatellite markers D15S1010, D15S1007, ACTC and D15S118 in 31 individuals from two families. The HMPS locus cosecretion of the markers on 15q13 over a region of 2.8 cM was confirmed by Haplotype and linkage analysis.</p><p><b>RESULTS</b>The disease of haplotype identified in one pedigree was not co-segregated with an affected individual while no definitive disease haplotype could be assigned for the second pedigree. The maximum two-point and multi-point LOD scores at ACTC for the two Chinese families are 0.20 (theta = 0.3) and -5.0 respectively.</p><p><b>CONCLUSIONS</b>Haplotype and linkage analysis indicate that the Ashkenazi haplotypes is not associated with HMPS in Singapore Chinese families, which suggests genetic heterogeneity.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Linhagem / Cromossomos Humanos Par 6 / Haplótipos / Neoplasias Colorretais / Polipose Adenomatosa do Colo / Predisposição Genética para Doença / Povo Asiático / Genética / Ligação Genética Tipo de estudo: Estudo prognóstico Limite: Adulto / Feminino / Humanos / Masculino Idioma: Chinês Revista: Chinese Journal of Gastrointestinal Surgery Ano de publicação: 2005 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Linhagem / Cromossomos Humanos Par 6 / Haplótipos / Neoplasias Colorretais / Polipose Adenomatosa do Colo / Predisposição Genética para Doença / Povo Asiático / Genética / Ligação Genética Tipo de estudo: Estudo prognóstico Limite: Adulto / Feminino / Humanos / Masculino Idioma: Chinês Revista: Chinese Journal of Gastrointestinal Surgery Ano de publicação: 2005 Tipo de documento: Artigo