Expression of gastrin and gastrin releasing peptide in patient's with gastric cancer by using tissue chip technique / 中华胃肠外科杂志
Chinese Journal of Gastrointestinal Surgery
; (12): 159-161, 2005.
Article
em Zh
| WPRIM
| ID: wpr-345213
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the expression of gastrin(GAS) and gastrin releasing peptide(GRP) in patients with gastric cancer and investigate the clinical significance.</p><p><b>METHODS</b>The expression of GAS and GRP in sixty patients with gastric cancer was detected by using tissue chip technique and immunohistochemical methods.</p><p><b>RESULTS</b>The positive rates of GAS and GRP were 30.0% and 11.7% respectively in 60 cases with gastric cancer. The positive rates of GAS and GRP were higher in moderately and poorly differentiated cancers than those in well differentiated cancer (P< 0.05). The positive rates of GAS and GRP were significantly higher in mucinous adenocarcinoma and signet-ring cell carcinoma than those in other types of gastric cancer (P< 0.05). The positive expression of GAS and GRP in gastric cancer was correlated with lymph node metastasis (P< 0.05).</p><p><b>CONCLUSION</b>Tissue chip technique is a feasible,rapid,economic and accurate approach for screening clinical tissue specimens on a large scale.</p>
Texto completo:
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Índice:
WPRIM
Assunto principal:
Patologia
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Neoplasias Gástricas
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Gastrinas
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Imuno-Histoquímica
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Peptídeo Liberador de Gastrina
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Análise Serial de Proteínas
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Metabolismo
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Métodos
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Invasividade Neoplásica
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Estadiamento de Neoplasias
Limite:
Adult
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Aged
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Chinese Journal of Gastrointestinal Surgery
Ano de publicação:
2005
Tipo de documento:
Article