Progress in research on genetic polymorphisms and sequence-based typing of KIR genes / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 867-870, 2016.
Artigo
em Chinês
| WPRIM
| ID: wpr-345344
ABSTRACT
Killer cell immunoglobulin-like receptors (KIRs) are members of the immunoglobulin superfamily expressed on natural killer (NK) cells and a subset of T cells. Given the receptor-ligand relationship between certain KIR and human leukocyte antigen (HLA) classⅠmolecules, the KIRs are involved in the regulation of NK cell activation through conveying activating or inhibitory signals, which plays an important role in immunities involved in transplantation, tumor, infection as well as autoimmune diseases. This paper has provided a review for the research on KIR gene polymorphisms and summarized the characteristics of the sequence-based typing method for KIR genes.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Polimorfismo Genético
/
Células Matadoras Naturais
/
Antígenos de Histocompatibilidade Classe I
/
Receptores KIR
/
Genética
/
Antígenos HLA
/
Metabolismo
Limite:
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Medical Genetics
Ano de publicação:
2016
Tipo de documento:
Artigo
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