Advances of research on the mechanism of Down syndrome birth at advanced maternal age / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 863-866, 2016.
Artigo
em Chinês
| WPRIM
| ID: wpr-345345
ABSTRACT
Down syndrome is caused by partial or complete triplication of genes located on chromosome 21. Its incidence increases dramatically with the age of women. Hypotheses proposed for this have included abnormal homologous recombination, defective spindle assembly, biological aging, reduction of cohesion complexes, endocrine disorders, oocyte selection model, and single nucleotide polymorphisms of genes that maintain chromosome stability, etc. A literature review is provided here.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Oócitos
/
Cromossomos Humanos Par 21
/
Envelhecimento
/
Idade Materna
/
Síndrome de Down
/
Polimorfismo de Nucleotídeo Único
/
Genética
/
Metabolismo
Limite:
Feminino
/
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Medical Genetics
Ano de publicação:
2016
Tipo de documento:
Artigo
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