Advances of research on the mechanism of Down syndrome birth at advanced maternal age / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 863-866, 2016.
Article
em Zh
| WPRIM
| ID: wpr-345345
Biblioteca responsável:
WPRO
ABSTRACT
Down syndrome is caused by partial or complete triplication of genes located on chromosome 21. Its incidence increases dramatically with the age of women. Hypotheses proposed for this have included abnormal homologous recombination, defective spindle assembly, biological aging, reduction of cohesion complexes, endocrine disorders, oocyte selection model, and single nucleotide polymorphisms of genes that maintain chromosome stability, etc. A literature review is provided here.
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Oócitos
/
Cromossomos Humanos Par 21
/
Envelhecimento
/
Idade Materna
/
Síndrome de Down
/
Polimorfismo de Nucleotídeo Único
/
Genética
/
Metabolismo
Limite:
Female
/
Humans
Idioma:
Zh
Revista:
Chinese Journal of Medical Genetics
Ano de publicação:
2016
Tipo de documento:
Article