Identification of a novel HLA allele A*29:49 using sequence based typing / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 841-843, 2016.
Artigo
em Chinês
| WPRIM
| ID: wpr-345350
ABSTRACT
<p><b>OBJECTIVE</b>To report on a novel HLA-A allele, A*2949, identified in a Chinese Han population by sequence based typing (SBT).</p><p><b>METHODS</b>A donor from China Marrow Donor Programme (CMDP) was typed with a bi-allelic PCR-SBT kit, and no full matched result was obtained for the HLA-A locus. The novel HLA allele was verified with an allele-specific amplification SBT kit.</p><p><b>RESULTS</b>A novel HLA-A allele was identified, which has differed by one nucleotide from the closest matched allele, HLA-A*29010101, at position 368(A→T), codon 99 (TAT→TTT), resulting in an amino acid substitution (Y→F). Another allele was verified as A*020601.</p><p><b>CONCLUSION</b>A novel HLA-A allele was identified and officially named as HLA-A*2949 by the WHO Nomenclature Committee for Factors of the HLA System.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Sequência de Bases
/
Antígenos HLA-A
/
China
/
Análise de Sequência de DNA
/
Substituição de Aminoácidos
/
Alelos
/
Genética
/
Métodos
Tipo de estudo:
Estudo diagnóstico
/
Estudo prognóstico
Limite:
Humanos
País/Região como assunto:
Ásia
Idioma:
Chinês
Revista:
Chinese Journal of Medical Genetics
Ano de publicação:
2016
Tipo de documento:
Artigo
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