Association of GCKR gene polymorphisms and type 2 diabetes among ethnic Uygurs / 中华医学遗传学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To assess the association of glucokinase regulator protein (GCKR) gene polymorphisms and type 2 diabetes (T2D) among ethnic Uygurs from Xinjiang, China.</p><p><b>METHODS</b>One thousand and six T2D patients and 1004 healthy controls were recruited. The rs780094 genotype of the GCKR gene was determined with a Sequenom Mass ARRAY system.</p><p><b>RESULTS</b>The distribution of GCKR rs780094 AA, AG and GG genotypes were not statistically different between the two groups (P>0.05). After adjusting confounding factors, an association of rs780094 with T2D was observed in an additive and dominant model (OR=1.181, 95%CI 1.021-1.366, P=0.025; OR=1.296, 95%CI 1.043-1.610, P=0.019). The total cholesterol level was higher in AA carriers than GG and GA carriers (P<0.05).</p><p><b>CONCLUSION</b>The AA genotype of the GCKR rs780094 polymorphism may increase the risk of T2D among ethnic Uygurs from Xinjiang.</p>