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Cholesterol concentrations in cord blood of newborn infants / 中华儿科杂志
Chinese Journal of Pediatrics ; (12): 107-109, 2003.
Artigo em Chinês | WPRIM | ID: wpr-345429
ABSTRACT
<p><b>OBJECTIVE</b>Familial hypercholesterolemia (FH) is an autosomal dominant disease with an estimated worldwide prevalence of 0.2%. It is caused by a multitude of low density lipoprotein receptor gene mutations. It is characterized with high levels of total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and a high incidence of coronary artery disease in young adults. Cord blood cholesterol concentration is used for mass screening of FH. The purpose of this study was to detect the lipid levels of cord blood in newborn infants from China and to determine the cut-off point after 1 to 2 years follow-up.</p><p><b>METHODS</b>TC, triglycerides (TG), LDL-C and high density lipoprotein cholesterol (HDL-C) were determined in 242 healthy full-term newborn infants.</p><p><b>RESULTS</b>The mean values of TC, TG, LDL-C and HDL-C in cord blood were (1.69 +/- 0.40) mmol/L, (0.23 +/- 0.12) mmol/L, (0.81 +/- 0.21) mmol/L and (0.58 +/- 0.16) mmol/L (mean +/- standard deviation), respectively. The HDL-C concentration in male neonates was lower than that in female neonates (P < 0.05).</p><p><b>CONCLUSION</b>After the follow-up of 1 to 2 years for FH, the recommended screening cut-off points were TC > or = 2.47 mmol/L and LDL-C > or = 0.89 mmol/L.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Triglicerídeos / Sangue / Química / China / Colesterol / Diagnóstico / Sangue Fetal / Hiperlipoproteinemia Tipo II / HDL-Colesterol / LDL-Colesterol Tipo de estudo: Estudo diagnóstico / Estudo de rastreamento Limite: Feminino / Humanos / Masculino / Recém-Nascido País/Região como assunto: Ásia Idioma: Chinês Revista: Chinese Journal of Pediatrics Ano de publicação: 2003 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Triglicerídeos / Sangue / Química / China / Colesterol / Diagnóstico / Sangue Fetal / Hiperlipoproteinemia Tipo II / HDL-Colesterol / LDL-Colesterol Tipo de estudo: Estudo diagnóstico / Estudo de rastreamento Limite: Feminino / Humanos / Masculino / Recém-Nascido País/Região como assunto: Ásia Idioma: Chinês Revista: Chinese Journal of Pediatrics Ano de publicação: 2003 Tipo de documento: Artigo