Correlations Between HLA-Cw*0602 and Clinical Picture in Korean Psoriatic Patients / 대한피부과학회지

ABSTRACT

BACKGROUND: HLA-Cw6 has the strongest individual association with psoriasis in many racial groups, and associations with the positive family history and early age at onset have been noted in many studies. OBJECTIVE: The aim of this study was to investigate whether Cw6 correlate with the clinical parameters of Korean psoriatic patients. METHODS: One hundred and twelve unrelated patients with psoriasis, and 166 healthy controls were examined with regard to Cw*0602, using a PCR-SSP method. We divided the patients into two groups according to Cw*0602 positivity, and compared two groups with reference to several clinical parameters. RESULTS: The results are summarized as follows 1. Cw*0602 was found in 69.6% of the 112 patients, but only in 9.0% of the 166 healthy controls(p<0.05, RR=23.1). 2. The presence of Cw*0602 correlated with early age at onset(26.1 vs. 32.5 years, p<0.05), and Cw*0602 was present in 75.0% of the patients with early onset(p<0.05, RR=30.2). 3. The presence of Cw*0602 did not correlate with a positive family history of psoriasis among the first-degree relatives, but correlated with an overall positive family history (p<0.05). 4. There were no positive correlations with arthritis, the history of inpatient treatment, the clinical type of psoriasis, and onset or exacerbation after upper respiratory infection. CONCLUSION: The presence of Cw*0602 correlated with a positive family history for psoriasis and early age at onset, but did not correlate with arthritis, the history of inpatient treatment, the clinical type of psoriasis, and onset or exacerbation after upper respiratory infection.