Randomized clinical trial of IEP and EP regimens in the treatment of patients with small cell lung cancer / 中国肺癌杂志
Chinese Journal of Lung Cancer
;
(12): 240-242, 2004.
Artigo
em Chinês
| WPRIM
| ID: wpr-345806
ABSTRACT
<p><b>BACKGROUND</b>To observe and compare the efficacy and safety of IEP and EP regimens for small cell lung cancer (SCLC).</p><p><b>METHODS</b>Sixty-four patients with SCLC pathologically proved were randomly divided into IEP group ( n =32) and EP group ( n =32).</p><p><b>RESULTS</b>All the 64 patients were evaluable for response and toxicity. In IEP group, the total responsive rate, responsive rates of limited-stage patients and extensive-stage patients were 84.4%(27/32), 100.0%(15/15) and 70.6%(12/17) respectively; while in EP group, those were 75.0%(24/32), 85.7%(12/14) and 66.7% (12/18) respectively. The median duration of remission was 6 months and 1-year survival rate was 62.5% in IEP group, and 5 months and 56.2% in EP group. There was no significant difference in response rate, median duration of remission and 1-year survival between the two groups ( P > 0.05). The main toxicity was myelosuppression. Incidences of leukopenia at grade III-IV, nausea, vomiting and alopecia were significantly higher in the IEP arm than those in the EP arm ( P < 0.01 ).</p><p><b>CONCLUSIONS</b>High response rates and tolerable toxicities are attainable for small cell lung cancer treated with IEP and EP. IEP regimen shows a similar response rate compared with EP regimen. They might be considered as relevant regimens in initial patients with small cell lung cancer.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Ensaio Clínico Controlado
Idioma:
Chinês
Revista:
Chinese Journal of Lung Cancer
Ano de publicação:
2004
Tipo de documento:
Artigo
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