Risk factors for early disseminated intravascular coagulation in neonates with sepsis / 中国当代儿科杂志

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the risk factors for early disseminated intravascular coagulation (DIC) in neonates with sepsis.</p><p><b>METHODS</b>A retrospective clinical study was performed on 100 neonates with a confirmed diagnosis of sepsis between 2012 and 2013. The children were classified into normal coagulation group, non-overt DIC group (early DIC group), and overt DIC group (late DIC group) based on the ISTH overt DIC scoring system. The clinical manifestations and risk factors were analyzed statistically.</p><p><b>RESULTS</b>Early DIC occurred in 44 (44%) cases in the 100 neonates with sepsis. The incidence of sclerema showed significant differences between the three groups (P<0.05). Asphyxia, bleeding, and Gram-negative bacterial infection were independent risk factors for early DIC.</p><p><b>CONCLUSIONS</b>Coagulation function should be actively monitored and early intervention measures should be taken for neonates with asphyxia, bleeding, and Gram-negative bacterial infection to prevent early DIC from progressing to late DIC.</p>