Plasma proteomic analysis in children with infectious mononucleosis / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 254-257, 2015.
Artigo
em Chinês
| WPRIM
| ID: wpr-346171
ABSTRACT
<p><b>OBJECTIVE</b>To explore the abnormal expression of plasma proteins by analysis of proteomic expression profile in children with infectious mononucleosis (IM).</p><p><b>METHODS</b>Two dimensional gel electrophoresis (2-DE) followed by the mass spectrometry was used to examine important protein spots with different expression levels between children with IM and normal controls.</p><p><b>RESULTS</b>Seven differential proteins were obtained hemopexin, vitamin D binding protein, fetuin A, C-reactive protein, apolipoprotein A, haptoglobin and transthyretin. Compared with the control group, haptoglobin showed a higher expression level in children with IM, and the expression levels of the other proteins were obviously down-regulated.</p><p><b>CONCLUSIONS</b>The expression changes of differential proteins identified in this study are all related with the liver acute injury, suggesting that children with IM are associated with acute liver injury. Further studies on the characteristics of above proteins will contribute to the diagnosis and treatment of pediatric IM.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Sangue
/
Proteínas Sanguíneas
/
Eletroforese em Gel Bidimensional
/
Proteômica
/
Mononucleose Infecciosa
/
Métodos
Tipo de estudo:
Estudo prognóstico
Limite:
Criança
/
Criança, pré-escolar
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Contemporary Pediatrics
Ano de publicação:
2015
Tipo de documento:
Artigo
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