The efficiency and safety of laparoscopic surgery for colorectal carcinoma: a systematic review / 中华外科杂志
Chinese Journal of Surgery
;
(12): 346-350, 2011.
Artigo
em Chinês
| WPRIM
| ID: wpr-346307
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate and compare the efficiency and safety of laparoscopic surgery (LS) and open surgery (OS) in the treatment of colorectal carcinoma.</p><p><b>METHODS</b>Randomized controlled trials on laparoscopic surgery and open surgery for colorectal carcinoma from January 2000 to October 2010 were searched in the databases of EMbase, PubMed, Cochrane Library, Sciencedirect, Springer, VIP, CNKI, CBMdisc. The methodological quality was assessed according to the standard of Cochrane systematic review. For homogeneous studies, RevMan5.0 software was used for meta-analysis.</p><p><b>RESULTS</b>A total of 13 RCTs involving 4603 patients were included in this study, and among those 6 were multi-center randomized controlled trials. The meta-analysis showed that the operation time of the LS group was longer than that of the OS group (WMD = 38.91, 95%CI 33.89 - 43.93, P < 0.001), the blood loss (WMD = -138.14, 95%CI -195.79 - -80.50, P < 0.001) and the length of hospital stay (WMD = 2.91, 95%CI -4.65 - -1.17, P = 0.001) of the LS group was less than those in OS group. There was no significant differences between the two groups in the number of dissected lymph nodes (WMD = -0.62, 95%CI -1.47 - 0.23, P = 0.150). There was no significant differences between the two groups in terms of the postoperative complications (30 days) (RR = 0.78, 95%CI 0.59 - 1.01, P = 0.06). There was no significant differences between the two groups in 3-year overall survival (RR = 1.00, 95%CI 0.96 - 1.04, P = 0.970). There was no significant differences between the two groups in 5-year overall survival (RR = 1.03, 95%CI 0.99 - 1.08, P = 0.140). There was no significant differences between the two groups in 5-year overall recurrence (RR = 0.89, 95%CI 0.74 - 1.07, P = 0.200).</p><p><b>CONCLUSIONS</b>Laparoscopic surgery for colorectal carcinoma is a safe and effective therapy as open surgery in the short term or long term outcomes. It could be an acceptable alternative to open surgery for colorectal carcinoma.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Cirurgia Geral
/
Neoplasias Colorretais
/
Ensaios Clínicos Controlados Aleatórios como Assunto
/
Resultado do Tratamento
/
Laparoscopia
Tipo de estudo:
Ensaio Clínico Controlado
/
Revisões Sistemáticas Avaliadas
Limite:
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Surgery
Ano de publicação:
2011
Tipo de documento:
Artigo
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