Fatal Ifosfamide-Induced Metabolic Encephalopathy in Patients with Recurrent Epithelial Ovarian Cancer: Report of Two Cases / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment
;
: 260-263, 2011.
Artigo
em Inglês
| WPRIM
| ID: wpr-34644
ABSTRACT
Central nervous system (CNS) toxicity has been reported in approximately 10-30% of patients receiving intravenous infusions of ifosfamide. Encephalopathy is a rare but serious CNS adverse reaction in these patients, and although usually transient and reversible, may cause persistent neurological dysfunction or death. Clinical features range from fatigue and confusion to coma and death. Although methylene blue can be used to treat ifosfamide-induced neurotoxicity, including encephalopathy, its mechanism of action remains poorly defined. We describe here two patients with recurrent epithelial ovarian cancer who experienced fatal encephalopathy following ifosfamide/mesna treatment.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Neoplasias Ovarianas
/
Infusões Intravenosas
/
Encefalopatias Metabólicas
/
Sistema Nervoso Central
/
Mesna
/
Coma
/
Neoplasias Epiteliais e Glandulares
/
Fadiga
/
Ifosfamida
/
Azul de Metileno
Limite:
Humanos
Idioma:
Inglês
Revista:
Cancer Research and Treatment
Ano de publicação:
2011
Tipo de documento:
Artigo
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