Protective effect of yixinshu capsule on myocardial ischemia reperfusion injury in rats / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 2005-2008, 2013.
Artigo
em Chinês
| WPRIM
| ID: wpr-346454
ABSTRACT
<p><b>OBJECTIVE</b>To observe the protective effect of Yixinshu capsule on myocardial ischemia reperfusion injury (MIRI) in SD rats.</p><p><b>METHOD</b>Sixty healthy SD rats were randomized into six groups sham group, MIRI model group, Xinsuning capsule group, low, middle or high dose Yixinshu capsule. Acute MIRI rat models were created by reperfusion for 120 min after anterior interventricular branch of the left coronary artery for 30 min. The serum creatine kinase (CK), lactic dehydrogenase (LDH), aspartate aminotransferase (AST) and malondialdehyde(MDA), blood viscosity, and infarction area of myocardium were determined.</p><p><b>RESULT</b>Yixinshu capsule could reduce serum CK, LDH, AST and LDH activity, improve the blood viscosity, and reduced the myocardial infarct size.</p><p><b>CONCLUSION</b>Yixinshu capsule can protect against MIRI in rats.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Viscosidade Sanguínea
/
Cápsulas
/
Medicamentos de Ervas Chinesas
/
Peroxidação de Lipídeos
/
Traumatismo por Reperfusão Miocárdica
/
Ratos Sprague-Dawley
/
Usos Terapêuticos
/
Tratamento Farmacológico
/
Metabolismo
Limite:
Animais
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2013
Tipo de documento:
Artigo
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