Study on pharmaceutical screening of representative components of Salvia miltiorrhiza diterpene quinones / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 1851-1855, 2013.
Artigo
em Chinês
| WPRIM
| ID: wpr-346484
ABSTRACT
<p><b>OBJECTIVE</b>To screen out the main components with no significant difference with Salvia miltiorrhiza diterpene quinones pharmacological action, in order to determine the compatible form of representative components that can describe the overall property of S. miltiorrhiza diterpene quinones.</p><p><b>METHOD</b>According to the results of the in vitro pharmacological experiment, the myocardial ischemia model of rats was induced through intraperitoneal injection of isoproterenol. The pharmacologic effects of S. miltiorrhiza diterpene quinones, combination with principal component A and combination with principal component B were compared in electrocardiogram (changes in J point), enzymology indicators (SOD, MDA, CK, LDH) and pathology (myocardial histological changes), so as to screen out the compatible form of representative components that can describe the overall property of S. miltiorrhiza diterpene quinones.</p><p><b>RESULT</b>The S. miltiorrhiza diterpenoid quinone high-dose group and the B high-dose group were similar in all pharmacological effects, with equal efficacy but no significant difference.</p><p><b>CONCLUSION</b>The S. miltiorrhiza diterpenoid quinone high-dose group and the B high-dose group showed a certain therapeutic effect on ISO-induced myocardial ischemia. Therefore, the four components in the B high-dose group can be used as representative components of S. miltiorrhiza diterpene quinones.</p>
Texto completo:
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Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Quinonas
/
Química
/
Ratos Sprague-Dawley
/
Isquemia Miocárdica
/
Salvia miltiorrhiza
/
Diterpenos
/
Avaliação Pré-Clínica de Medicamentos
/
Tratamento Farmacológico
/
Isoproterenol
Tipo de estudo:
Estudo diagnóstico
/
Estudo de rastreamento
Limite:
Animais
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2013
Tipo de documento:
Artigo
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