Pharmacokinetics behavior of raltitrexed in rats after single injected with astragali radix / 中国中药杂志

ABSTRACT

To study pharmacokinetics behavior of Raltitrexed (RTX) after single injected with Radix Astragali (RA); twelve rats were divided into two groups RTX (administrated iv. of raltitrexed); RTX with RA (administrated iv. of raltitrexed after single iv. dose of 3. 15 g x kg(-1)), rat plasma was collected and processed before HPLC assays; The established HPLC method was rapid, specific and precise. Between RTX and RTX with RA groups, half-life (t1/2), AUC(0-t) and CL showed no statistically significant differences; RA co-administration did not affect the pharmacokinetics of raltitrexed.