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Genetic polymorphism of tumor necrosis factor-alpha in patients with chronic benzene poisoning / 中华劳动卫生职业病杂志
Chinese Journal of Industrial Hygiene and Occupational Diseases ; (12): 195-198, 2005.
Artigo em Chinês | WPRIM | ID: wpr-346533
ABSTRACT
<p><b>OBJECTIVE</b>To study the relationship between genetic polymorphism of tumor necrosis factor-alpha (TNF-alpha, sites at -238 nt and -308 nt) and susceptibility to chronic benzene poisoning.</p><p><b>METHOD</b>The polymorphism of TNF-alpha gene were detected by nested polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique from 50 benzene poisoning patients and 60 control individuals exposed to benzene.</p><p><b>RESULTS</b>The frequency of the TNF-alpha-238G/G, A/G and A/A in controls (95%, 5% and 0%, respectively), were not significantly different from those in patients (92%, 6% and 2%, respectively, P > 0.05). The frequency of the TNF-alpha-308G/G, A/G and A/A in patients were 76%, 24% and 0% respectively, and that in control individuals were 93%, 7% and 0% respectively. Chi(2) test showed that frequency of TNF-alpha-308A/G in patients was significantly higher than that in controls (chi(2) = 6.22, P = 0.013). Logistic analysis showed that TNF-alpha-308A/G was the independent risk factor of benzene poisoning (OR = 5.3, P < 0.05).</p><p><b>CONCLUSION</b>Individuals with TNF-alpha-308A/G gene polymorphism are susceptible to benzene poisoning.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Intoxicação / Polimorfismo Genético / Benzeno / Polimorfismo de Fragmento de Restrição / Reação em Cadeia da Polimerase / Doença Crônica / Fator de Necrose Tumoral alfa / Predisposição Genética para Doença / Genética / Genótipo Tipo de estudo: Fatores de risco Limite: Adulto / Feminino / Humanos / Masculino Idioma: Chinês Revista: Chinese Journal of Industrial Hygiene and Occupational Diseases Ano de publicação: 2005 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Intoxicação / Polimorfismo Genético / Benzeno / Polimorfismo de Fragmento de Restrição / Reação em Cadeia da Polimerase / Doença Crônica / Fator de Necrose Tumoral alfa / Predisposição Genética para Doença / Genética / Genótipo Tipo de estudo: Fatores de risco Limite: Adulto / Feminino / Humanos / Masculino Idioma: Chinês Revista: Chinese Journal of Industrial Hygiene and Occupational Diseases Ano de publicação: 2005 Tipo de documento: Artigo