Genetic polymorphism of tumor necrosis factor-alpha in patients with chronic benzene poisoning / 中华劳动卫生职业病杂志
Chinese Journal of Industrial Hygiene and Occupational Diseases
;
(12): 195-198, 2005.
Artigo
em Chinês
| WPRIM
| ID: wpr-346533
ABSTRACT
<p><b>OBJECTIVE</b>To study the relationship between genetic polymorphism of tumor necrosis factor-alpha (TNF-alpha, sites at -238 nt and -308 nt) and susceptibility to chronic benzene poisoning.</p><p><b>METHOD</b>The polymorphism of TNF-alpha gene were detected by nested polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique from 50 benzene poisoning patients and 60 control individuals exposed to benzene.</p><p><b>RESULTS</b>The frequency of the TNF-alpha-238G/G, A/G and A/A in controls (95%, 5% and 0%, respectively), were not significantly different from those in patients (92%, 6% and 2%, respectively, P > 0.05). The frequency of the TNF-alpha-308G/G, A/G and A/A in patients were 76%, 24% and 0% respectively, and that in control individuals were 93%, 7% and 0% respectively. Chi(2) test showed that frequency of TNF-alpha-308A/G in patients was significantly higher than that in controls (chi(2) = 6.22, P = 0.013). Logistic analysis showed that TNF-alpha-308A/G was the independent risk factor of benzene poisoning (OR = 5.3, P < 0.05).</p><p><b>CONCLUSION</b>Individuals with TNF-alpha-308A/G gene polymorphism are susceptible to benzene poisoning.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Intoxicação
/
Polimorfismo Genético
/
Benzeno
/
Polimorfismo de Fragmento de Restrição
/
Reação em Cadeia da Polimerase
/
Doença Crônica
/
Fator de Necrose Tumoral alfa
/
Predisposição Genética para Doença
/
Genética
/
Genótipo
Tipo de estudo:
Fatores de risco
Limite:
Adulto
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Industrial Hygiene and Occupational Diseases
Ano de publicação:
2005
Tipo de documento:
Artigo
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