Your browser doesn't support javascript.
loading
Roles of matrix metalloproteinases and tissue specific inhibitors of metalloproteinases in dentinogenic ghost cell tumor and ghost cell odontogenic carcinoma / 中华口腔医学杂志
Chinese Journal of Stomatology ; (12): 756-760, 2008.
Artigo em Chinês | WPRIM | ID: wpr-346791
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the roles of matrix metalloproteinases (MMP) and tissue inhibitors of metalloproteinases (TIMP) in dentinogenic ghost cell tumor (DGCT) and ghost cell odontogenic carcinoma (GCOC).</p><p><b>METHODS</b>The expressions of MMP-2, MMP-9, MMP-14, TIMP-1 and TIMP-2 were examined in 15 DGCT cases and 9 GCOC cases by immunohistochemistry. Their mRNA expression in one DGCT case and one GCOC case were investigated by RT-PCT.MMP-2 and MMP-9 protein activities in the two cases were analyzed by gelatin zymography.</p><p><b>RESULTS</b>MMP-9 and TIMP-1 expressions elevated greatly in GCOC, and there was a significant difference (P < 0.05) in TIMP-1 expression between GCOC and DGCT.Pro-MMP-9, MMP-9 activated form, pro-MMP-2, and MMP-2 activated forms were detected in the GCOC case, while pro-MMP-9 and MMP-9 activated form were very faint in the DGCT case. The mRNA level of MMP-9 elevated obviously in the GCOC case, which was similar to that of TIMP-1.</p><p><b>CONCLUSIONS</b>The elevated expression of MMP-9 and TIMP-1 may influence the behaviour of GCOC.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Patologia / Neoplasias Mandibulares / Tumores Odontogênicos / Inibidores Teciduais de Metaloproteinases / Metaloproteinases da Matriz / Dentina / Metabolismo Limite: Adolescente / Adulto / Idoso / Criança / Humanos Idioma: Chinês Revista: Chinese Journal of Stomatology Ano de publicação: 2008 Tipo de documento: Artigo

Similares

MEDLINE

...
LILACS

LIS

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Patologia / Neoplasias Mandibulares / Tumores Odontogênicos / Inibidores Teciduais de Metaloproteinases / Metaloproteinases da Matriz / Dentina / Metabolismo Limite: Adolescente / Adulto / Idoso / Criança / Humanos Idioma: Chinês Revista: Chinese Journal of Stomatology Ano de publicação: 2008 Tipo de documento: Artigo