Study on andrographolide solid dispersion vectored by hydroxyapatite / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To prepare andrographolide solid dispersion, with hydroxyapatite as vector, in order to increase drug dissolution.</p><p><b>METHOD</b>Andrographolide and hydroxyapatite were dispersed in 95% ethanol. The solvent evaporation method was adopted to prepare andrographolide solid dispersion, in order to study its dissolution behavior, stability and physical characteristics.</p><p><b>RESULT</b>The solid dispersion prepared with andrographolide and hydroxyapatite with the proportion of 1:8 existed in the vector in an amorphous form, according to differential scanning calorimetry, scanning electron microscopy and X-ray powder diffraction. The in vitro dissolution of andrographolide solid dispersions was up to 93% at 45 min. After the accelerated stability test for three months, the drug dissolution and content in andrographolide solid dispersion showed no significant change.</p><p><b>CONCLUSION</b>The prepared solid dispersions with hydroxyapatite as the vector can effectively improve the stability and dissolution of water-insoluble drug andrographolide.</p>