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Study on treatment effect and mechanism of Hirsutella sinensis mycelium in idiopathic pulmonary fibrosis in rats / 中国中药杂志
Article em Zh | WPRIM | ID: wpr-346896
Biblioteca responsável: WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study and discuss the effect and mechanism of Hirsutella sinensis mycelium (HSM) on idiopathic pulmonary fibrosis in rats.</p><p><b>METHOD</b>Forty Wistar rats were divided into five groups: the normal control group, the model control group, the high-dose group (1.0 g x kg(-1) HSM), the low-dose group (0.5 g x kg(-1) HSM), and the positive control group (10 mg x kg(-1) hydrocortisone). In addition to rats in the normal control group, the pulmonary fibrosis model was established by injecting 5 mg x kg(-1) bleomycin into rat tracheas for consecutively 28 days, in order to observe their lung function, lung tissue hydroxyproline, cytokines and pathology.</p><p><b>RESULT</b>After rats were administered with HSM, 0.5 g x kg(-1) and 1.0 g x kg(-1) HSM could significantly decrease lung index and hydroxyproline content (P<0.01), while notably improving pulmonary function, alveolus inflammation and fibrosis degree (P<0.05, P<0.01); 1.0 g x kg(-1) HSM could decrease significantly protein expressions of TNF-alpha, IL-1beta and TGF-beta1 in lung tissues, while increasing significantly protein expressions of IFN-gamma (P<0.05).</p><p><b>CONCLUSION</b>HSM have better effect in treating idiopathic pulmonary fibrosis in rats. Its treatment effect and mechanism are related to the regulation of TNF-alpha, IL-1beta and TGF-beta1 and IFN-gamma imbalance.</p>
Assuntos
Texto completo: 1 Índice: WPRIM Assunto principal: Patologia / Química / Fator de Necrose Tumoral alfa / Resultado do Tratamento / Ratos Wistar / Micélio / Modelos Animais de Doenças / Tratamento Farmacológico / Fator de Crescimento Transformador beta1 / Fibrose Pulmonar Idiopática Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: Zh Revista: China Journal of Chinese Materia Medica Ano de publicação: 2012 Tipo de documento: Article
Texto completo: 1 Índice: WPRIM Assunto principal: Patologia / Química / Fator de Necrose Tumoral alfa / Resultado do Tratamento / Ratos Wistar / Micélio / Modelos Animais de Doenças / Tratamento Farmacológico / Fator de Crescimento Transformador beta1 / Fibrose Pulmonar Idiopática Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: Zh Revista: China Journal of Chinese Materia Medica Ano de publicação: 2012 Tipo de documento: Article