Comparison of anti-inflammatory effect and analysis of astilbin red and white transverse section Smilax glabra in 28 collection sites / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 3595-3598, 2012.
Article
em Zh
| WPRIM
| ID: wpr-346900
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>Astilbin in 28 Smilax glabra (red and white cross-section) from different sources was determined by HPLC. Pharmacodynamics and component of S. glabra was investigated through inflammation experiment (penetration type).</p><p><b>METHOD</b>The analysis was performed on a Hypersil ODS2 column (4.6 mm x 250 mm, 5 microm) with the mobile phase of acetonitrile and 0. 1% acetic acid aqueous (21: 79) at a flow rate of 1.0 mL x min(-1). The detection wavelength was 291 nm, and the column temperature was 25 degrees C. Anti-inflammatory effect was compared from two type cross-section of Smilax glabra in capillary permeability experiment.</p><p><b>RESULT</b>Linear correlation was good in the range of 0.003 379-4.004 microg, and the average recoveries were 100.1%, 101.9%, 99.3%, respectively. The content of astilbin in white and red transverse section were 0.19%-2.46% and 2.10%-5.92%, respectively. Anti-inflammatory efficiency of sectioned red and white were were 21% and 32%, respectively.</p><p><b>CONCLUSION</b>Astilbin content and anti-inflammatory effect is significantly different between red and white transverse section of S. glabra, the content of astilbin is not positively related with anti-inflammatory effect.</p>
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Índice:
WPRIM
Assunto principal:
Permeabilidade
/
Farmacologia
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Medicamentos de Ervas Chinesas
/
Química
/
China
/
Cromatografia Líquida de Alta Pressão
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Smilax
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Flavonóis
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Anti-Inflamatórios
Limite:
Animals
País/Região como assunto:
Asia
Idioma:
Zh
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2012
Tipo de documento:
Article