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Transfection of the nm23-H1 gene into BcaCD885 cell line inhibits the potential of invasion, adhesion and mobility / 中华口腔医学杂志
Chinese Journal of Stomatology ; (12): 16-19, 2003.
Artigo em Chinês | WPRIM | ID: wpr-347316
ABSTRACT
<p><b>OBJECTIVE</b>To transfect nm23-H1 into the BcaCD885 cell lines in order to get safe high-efficiency and low-toxicity, and to find out whether nm23-H1 could affect the invasion and metastases ability of BcaCD885 cell lines.</p><p><b>METHODS</b>Lipofect was used to transfect nm23-H1 into BcaCD885 cell lines; immunohistochemistry was used to detect the difference expression of nm23-H1 between transfected and non-transfected cell lines; then transwell-room and wash way were used to detect the difference of invasion and metastases ability between transfected and non-transfected cell lines.</p><p><b>RESULTS</b>PCMV-NEO-BAM system gave the stability expression of nm23-H1; there was significant different NDPKA expression between transfected and non-transfected BcaCD885 cell lines; the invasion and metastases ability of transfected BcaCD885 cell lines decreased obviously.</p><p><b>CONCLUSION</b>nm23-H1 can inhibit the metastases of BcaCD885 cell lines significantly.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Patologia / Fisiologia / Fatores de Transcrição / Neoplasias Bucais / Células Tumorais Cultivadas / Transfecção / Adesão Celular / Movimento Celular / Núcleosídeo-Difosfato Quinase / Proteínas Monoméricas de Ligação ao GTP Limite: Humanos Idioma: Chinês Revista: Chinese Journal of Stomatology Ano de publicação: 2003 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Patologia / Fisiologia / Fatores de Transcrição / Neoplasias Bucais / Células Tumorais Cultivadas / Transfecção / Adesão Celular / Movimento Celular / Núcleosídeo-Difosfato Quinase / Proteínas Monoméricas de Ligação ao GTP Limite: Humanos Idioma: Chinês Revista: Chinese Journal of Stomatology Ano de publicação: 2003 Tipo de documento: Artigo