Relation of heparanase mRNA expression and angiogenesis to the progression of gastric carcinoma / 中华肿瘤杂志
Chinese Journal of Oncology
; (12): 368-371, 2003.
Article
em Zh
| WPRIM
| ID: wpr-347422
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relation of heparanase gene and angiogenesis with the progress of gastric carcinoma (GC).</p><p><b>METHODS</b>Expression of heparanase mRNA in 52 GC tissue was detected by in situ hybridization assay. Microvessel density (MVD) was examined by immunohistochemical method. MVD and heparanase mRNA expression were analysed with their relation to histological grade, invasion depth,lymph node metastasis and organ metastasis.</p><p><b>RESULTS</b>MVD was 73.2 +/- 22.8 in 25 (48.1%) tissue with positive heparanase mRNA. It was 44.8 +/- 11.9 in 27 (51.9%) tissues with negative heparanase mRNA, between which the difference was significant (P < 0.001). MVD and heparanase mRNA expression were related with lymph node metastasis and depth of serosal invasion in GC (P < 0.005).</p><p><b>CONCLUSION</b>Heparanase, being related to angiogenesis in gastric cancer, promotes growth, invasion and metastasis. Heparanase mRNA expression is an important predictor of the biological behavior of human gastric carcinoma.</p>
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Índice:
WPRIM
Assunto principal:
Patologia
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Neoplasias Gástricas
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RNA Mensageiro
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Adenocarcinoma
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Regulação Neoplásica da Expressão Gênica
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Mucosa Gástrica
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Genética
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Glucuronidase
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Metástase Linfática
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Microcirculação
Limite:
Adult
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Aged
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Chinese Journal of Oncology
Ano de publicação:
2003
Tipo de documento:
Article