D-limonene induces apoptosis of gastric cancer cells / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 325-327, 2003.
Artigo
em Chinês
| WPRIM
| ID: wpr-347434
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the apoptosis effect induced by D-limonene on BGC-823 gastric cancer cells.</p><p><b>METHODS</b>The expression of p53, bc1-2 in BGC-823 cells and qualitative, quantitative index of cell apoptosis were detected with MTT, electron microscopy, flow cytometry and immunohistochemical method.</p><p><b>RESULTS</b>D-limonene could induce the formation of apoptotic bodies in a dose- and time-dependent manner. The expression of bcl-2 protein decreased and p53 protein increased in BGC-823 cells treated with D-limonene, compared with the control cells.</p><p><b>CONCLUSION</b>D-limonene exerts its cytotoxic effect on BGC-823 gastric cancer cells by inducing apoptosis.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Farmacologia
/
Neoplasias Gástricas
/
Terpenos
/
Adenocarcinoma
/
Proteína Supressora de Tumor p53
/
Apoptose
/
Proteínas Proto-Oncogênicas c-bcl-2
/
Linhagem Celular Tumoral
/
Relação Dose-Resposta a Droga
Tipo de estudo:
Pesquisa qualitativa
Limite:
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Oncology
Ano de publicação:
2003
Tipo de documento:
Artigo
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