The evaluation of LFH or LFPH in the treatment of advanced cancer of gastric cardia and colorectal cancer / 中华肿瘤杂志
Chinese Journal of Oncology
; (12): 289-291, 2003.
Article
em Zh
| WPRIM
| ID: wpr-347439
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the therapeutic effects of hydroxycamptothecin (H) combined with leucovorin (L), fluorouracil (F) and cisplatin (P) on advanced cancer of gastric cardia and colorectal cancer.</p><p><b>METHODS</b>Sixty-five patients with advanced cancer of gastric cardia or colorectal cancer were treated by LFH or LFPH regimen. All patients completed four cycles of treatment, in 21 days per cycle.</p><p><b>RESULTS</b>The overall response rate (RR) was 26.2% (17/65) with partial response (PR) in 17 patients, stable disease (SD) in 31 and progressive disease (PD) in 17. The clinical benefit response rate (CR + PR + SD) was 73.8% (48/65). The RR were 32.3% (10/31) for untreated patients and 20.6% (7/34) for retreated patients. The stable rate was 47.7% (31/65). The RR of patients with cancer of gastric cardia were 33.3% (5/15) for untreated treatment and 29.4% (5/17) for retreated ones. Median survival time (MST) was 10 months. Median time to progression (MTTP) was 8 months. Grade 3 - 4 toxicities were stomatitis (10.8%), nausea and vomiting (12.3%) and leukopenia (6.2%). Most patients (> 80%) developed Grade 1 - 2 alopecia.</p><p><b>CONCLUSION</b>The regimen of HCPT combined with LV, 5-Fu and DDP appears to be an effective and tolerable therapeutic option for advanced cancer of gastric cardia and colorectal cancer, especially for the former and retreated patients, giving a satisfactory stable rate though not very high.</p>
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Neoplasias Gástricas
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Camptotecina
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Cárdia
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Neoplasias Colorretais
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Protocolos de Quimioterapia Combinada Antineoplásica
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Leucovorina
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Mortalidade
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Cisplatino
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Usos Terapêuticos
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Tratamento Farmacológico
Tipo de estudo:
Prognostic_studies
Limite:
Adult
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Aged
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Chinese Journal of Oncology
Ano de publicação:
2003
Tipo de documento:
Article