Clinical features of hepatitis-associated aplastic anemia in children / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 609-612, 2010.
Artigo
em Chinês
| WPRIM
| ID: wpr-347531
ABSTRACT
<p><b>OBJECTIVE</b>To study the clinical features of hepatitis-associated aplastic anemia (HAAA) in children.</p><p><b>METHODS</b>The clinical data of the children with newly diagnosed HAAA from January 2007 to December 2008 were respectively studied, including clinical manifestations, and blood routine, bone marrow examination, viral serology and immune function results as well as treatment and prognosis.</p><p><b>RESULTS</b>A total of 8 children were confirmed as HAAA, accounting for 4.9% in children with aplastic anemia. There were 7 males and 1 female. The median age was 7.5 years (range 4.4 to 10.3 years) at diagnosis. They had negative serologic results and the causes of hepatitis could not be identified. The median interval from hepatitis occurrence to blood cell reduction was 6 weeks. Three cases were diagnosed as severe aplastic anemia and 5 cases as very severe aplastic anemia. Severe T cell immune disorders were found in all 8 cases. The percentage of Ts cells increased and the percentage of Th cells decreased significantly in the 8 children with HAAA. Four children survived after immune suppress treatment, three children died within one month after diagnosis and one child required own discharge without treatment.</p><p><b>CONCLUSIONS</b>HAAA is more frequent in male school children. The children with HAAA have severe T cell immune disorders, with a higher early death rate. Immune suppress treatment is effective.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Prognóstico
/
Terapêutica
/
Alergia e Imunologia
/
Hepatite
/
Anemia Aplástica
Tipo de estudo:
Estudo prognóstico
Limite:
Criança
/
Criança, pré-escolar
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Contemporary Pediatrics
Ano de publicação:
2010
Tipo de documento:
Artigo
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